Introduction: Asthma is a common chronic complex inflammatory airway disorder characterized by variable degrees of recurring symptoms of airflow obstruction and bronchial hyperresponsiveness. The prevalence of symptoms of gastro esophageal reflux among individuals with asthma is substantially higher than in normal population and similarly the prevalence of asthma in individuals with gastro esophageal reflux is also higher than in normal population. Objectives: To identify role of adding proton pump inhibitor to asthma medications of uncontrolled asthmatic children on the level of asthma control. Method: one hundered children with uncontrolled asthma (5 year to 12 years of age), included in our study in the period from october 2014 to june 2016 all of them were regularly followed up in the allergy clinic of alhussien university hospital and devided into to equal groups (study and control) with adding proton pump inhibitor to the study group with asthma medications and follow up the level of asthma control within 3monthes .Results: 28 patient of the 50 study group taken proton pump inhibitor with asthma medications show significant improvement in the level of asthma control and school achievement and the rest is un affected while only 22 of the 50 control group show improvement by usual ashma medicayions without adding proton pump inhibitor while the rest show deterioration of the level of their control Conclusion: we can add proton pump inhibitor with usual ashma medications to children wih difficulty in controlling asthma recommendation: we recommend futher wider studies wih proton pump inhibitor and other anti reflux medications.