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77259

SERUM GLIAL FIBRILLARY ACIDIC PROTEIN AS BIOMARKER IN NEONATES WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY

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Last updated: 04 Jan 2025

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Abstract

Introduction: Hypoxic ischemic encephalopathy (HIE) is a potentially devastating condition  accounts for 25% of all neonatal deaths , 40% will be affected by blindness, deafness, autism,, epilepsy, or other long-term complications( Felipe et al., 2013).
Aim of work: Assessment of the level of serum glial fibrillary acidic protein (GFAP) in neonate with hypoxic ischemic encephalopathy to early identify neonates with poor prognosis.                                        
Patients and Methods: This study is a case-control study was carried out on 50 neonates babies, they were selected from (NICU) of Bab Elsharia hospital in Cairo during the period from October 2016 to March 2018.
Results: In our study we found that there was statistically significant correlation between GFAP at 24 hours age and this demonstrate a concentration-dependent relationship between serum GFAP at birth and the severity of encephalopathy (Chalak et al. (2014). 
Conclusion: Serial increase in level GFAP from birth in HIE neonates and the severity of the hypoxic-ischemic injury can be stratified at birth and postnatal   because elevated GFAP in serum correlated with severity of HIE.
Recommendations: Measurement of serum GFAP in HIE within 24 hours postnatal but with large sample to early identify neonates with poor prognosis.

DOI

10.21608/azjp.2018.77259

Keywords

Glial fibrilary acidic protein, hypoxic ischemic encephalopathy

Authors

First Name

Ibrahim

Last Name

Soliman Ibrahim

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Email

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City

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Orcid

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First Name

Ahmed

Last Name

Mohamed Ismail

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Ahmed

Last Name

Helal Elsaid

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Kamel

Last Name

Soliman Hamad

MiddleName

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Affiliation

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Email

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City

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Orcid

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Volume

21

Article Issue

2

Related Issue

11558

Issue Date

2018-06-01

Receive Date

2020-03-13

Publish Date

2018-06-01

Page Start

2,173

Page End

2,184

Print ISSN

1110-7774

Online ISSN

3009-7770

Article File

AZJP_Volume 21_Issue 2_Pages 2173-2184.pdf

PDF . 225.7kB

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https://azjp.journals.ekb.eg/article_77259.html

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https://azjp.journals.ekb.eg/service?article_code=77259

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Type

Original Article

Type Code

1,135

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pediatrics

Publication Link

https://azjp.journals.ekb.eg/

MainTitle

SERUM GLIAL FIBRILLARY ACIDIC PROTEIN AS BIOMARKER IN NEONATES WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY

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Article

Created At

22 Jan 2023