Background: The present study was a Descriptive case-control study done that included infants of diabetic mothers with respiratory distress syndrome and infants of diabetic mothers without respiratory distress syndrome. Healthy full-term neonates were also included as a control.
Infants of diabetic mothers are frequently suffered from several cardiac and respiratory complications.
Cardiovascular compromise is a common complication of neonatal respiratory distress syndrome (RDS).
Our study assessed the diastolic function in infants of diabetic mothers with RDS and report that they are more likely to develop increase diastolic dysfunction than infants of non-diabetic mothers.
Aim: The purpose of this study was to assess the diastolic function of right and left ventricles using Conventional Doppler and Tissue Doppler Imaging (TDI) in infants of diabetic mothers with RDS and infants of diabetic mothers without RDS.
Methods: The study was conducted in neonatal intensive care unit (NICU) in Bab-Alsheria hospital, Pediatric department, Faculty of medicine, Al-Azhar University, cairo, in the period from June 2018 to February 2019 . The present work was conducted on forty neonates IDM ( 20 with RDS, 20 without RDS) and 20 (control), the degree of RDS was clinically scored by Downes' score All have: Detailed history- clinical examination-Plain X-ray- Tissue Doppler Imaging (TDI) and Doppler echocardiographic .
Results: Show significant higher value in IVS, Mitral A wave velocity and Tricuspid A wave velocity in IDMs with RDS compared to IDMs without RDS and control group. And significant lower values in Mitral E-wave velocity, Mitral E/A ratio, Tricuspid E-wave velocity, and Tricuspid E/A ratio in IDMs with RDS compared to IDMs without RDS and control group . Tissue Doppler Imaging (TDI) shows both the left and right ventricle myocardial velocities were found to be lower in the infant of diabetic mothers with RDS compared to the control group.
Conclusion: Infants of diabetic mothers with RDS are more prone to diastolic dysfunction and increase myocardial thickness compared with AGA- infants of diabetic mothers without RDS and control group.