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70223

EVALUATION OF SERUM IRON AND TRANSFERRIN IN IDIOPATHIC NEPHROTIC SYNDROME PATIENTS ATTENDING AL-HUSSEIN PEDIATRIC NEPHROLOGY CLINIC

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Last updated: 25 Dec 2024

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Abstract

Background: Nephrotic syndrome is characterized by excessive urinary excretion of albumin and other intermediated-size plasma proteins such as transferrin.. Excessive urinary losses of transferrin can produce low serum transferrin level that may lead to low plasma iron concentration and consequently the development of iron resistant microcytic hypochromic anemia. Aim of the Work: To evaluate changes in serum iron and transferrin and the relationship between the serum and urinary transferrin in the active and remission state of nephrotic syndrome Patients & Methods: The present work included fifty children with idiopathic nephrotic syndrome (INS), divided into 2 groups: group A (25 cases in activity) and group B (25 cases in remission). These two groups were age and sex matched with a mean age of (7.74 ± 2.45). All patients in this work were clinically evaluated together with routine laboratory investigations. Levels of serum albumin, urinary alb. /creatinine, serum iron, serum ferritin, serum transferrin and urinary transferrin were measured. Results: This work shows that the level of hemoglobin, MCV, HCT were statistically significantly lower in the cases in active state than cases in remission. The mean serum iron, serum ferritin and serum transferrin were significantly lower in the cases in active state than in the cases in remission .The mean urinary transferrin was statistically significantly higher in the cases in active state than in the cases with remission. Conclusion: Urinary transferrin can be considered a reliable parameter for early prediction of iron deficiency anemia in children with active nephrotic syndrome.

DOI

10.21608/azjp.2019.70223

Keywords

Hemoglobin (HG), Mean corpuscular volume (MCV) Albumin/creatinine ratio (alb. /creat) iron deficiency anemia, serum iron, transferrin

Authors

First Name

Ahmed Elsayed

Last Name

Darwish

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Orcid

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First Name

Moftah

Last Name

Mohamed Rabeea

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First Name

Nayera Mahmoud

Last Name

Al-Akkad

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First Name

Gamal Zakariya

Last Name

El-Morsi

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Volume

22

Article Issue

3

Related Issue

10649

Issue Date

2019-07-01

Receive Date

2020-02-06

Publish Date

2019-07-01

Page Start

403

Page End

424

Print ISSN

1110-7774

Online ISSN

3009-7770

Article File

AZJP_Volume 22_Issue 3_Pages 403-424.pdf

PDF . 394.5kB

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https://azjp.journals.ekb.eg/article_70223.html

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https://azjp.journals.ekb.eg/service?article_code=70223

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7

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Original Article

Type Code

1,135

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pediatrics

Publication Link

https://azjp.journals.ekb.eg/

MainTitle

EVALUATION OF SERUM IRON AND TRANSFERRIN IN IDIOPATHIC NEPHROTIC SYNDROME PATIENTS ATTENDING AL-HUSSEIN PEDIATRIC NEPHROLOGY CLINIC

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Article

Created At

22 Jan 2023