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68028

FIBROBLAST GROWTH FACTOR 23 AND CAROTID ARTERY INTIMAL MEDIUM THICKNESS IN CHILDREN WITH CHRONIC KIDNEY DISEASE

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Last updated: 04 Jan 2025

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Abstract

Background: The cause of early-accelerated atherosclerosis development observed in chronic kidney disease (CKD) is not fully understood. The determination of the relationship between the levels of fibroblast growth factor 23 (FGF-23) and carotid artery intimal medium thicknesses (CIMT) and development of endothelial dysfunction lends support to the possibility that FGF-23 plays a role in the development of atherosclerosis in CKD.
Objectives: to assess the circulating FGF23 as a marker of vascular stiffness in children with CKD regardless the etiology and to correlate its level with carotid artery intimal medium thickness as detected by Doppler U/S.
Patients and Methods: This is a prospective case control study was done on forty cases with CKD on conservative treatment (stage II - III and IV) regardless the etiology. Also twenty of apparently healthy children age and sex matched with cases were included as a control group. After complete clinical evaluation of cases and controls including weight, height, body mass index, blood pressure and all body systems, FGF23 was measured and carotid artery intimal medium thicknesses (CIMT) was measured as a marker of atherosclerosis using Doppler U/S.
Results: CIMT measurements and FGF-23 levels were significantly higher in patients than controls. There was positive correlation between FGF23 and CIMT, CKD stage. On the other hand there was negative correlation between FGF23 and GFR.
Conclusion: FGF-23 may be used as a sensitive and non-invasive indicator of subclinical atherosclerosis in patients with chronic kidney disease where our results showed a positive correlation between FGF23 and CIMT.  

DOI

10.21608/azjp.2019.68028

Keywords

Chronic Kidney Disease, Fibroblast Growth Factor 23, Carotid Artery Intimal Medium Thicknesses, Glomerular Filtration Rate

Authors

First Name

Hazem

Last Name

Abd El-Wahab

MiddleName

El- Sayed Mohammed

Affiliation

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Email

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City

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Orcid

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First Name

Moftah

Last Name

Rabeea

MiddleName

Mohammed

Affiliation

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Email

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City

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Orcid

-

First Name

Nayera

Last Name

El-Akkad

MiddleName

Mahmoud

Affiliation

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Email

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City

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Orcid

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First Name

Mohammed

Last Name

Shahin

MiddleName

Yousry

Affiliation

-

Email

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City

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Orcid

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First Name

Mustafa

Last Name

Sonbol

MiddleName

Fadel Mohammed

Affiliation

-

Email

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City

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Orcid

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Volume

22

Article Issue

1

Related Issue

10258

Issue Date

2019-01-01

Receive Date

2019-01-01

Publish Date

2019-01-01

Page Start

96

Page End

110

Print ISSN

1110-7774

Online ISSN

3009-7770

Article File

AZJP_Volume 22_Issue 1_Pages 96-110.pdf

PDF . 461.5kB

Link

https://azjp.journals.ekb.eg/article_68028.html

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https://azjp.journals.ekb.eg/service?article_code=68028

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6

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Original Article

Type Code

1,135

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pediatrics

Publication Link

https://azjp.journals.ekb.eg/

MainTitle

FIBROBLAST GROWTH FACTOR 23 AND CAROTID ARTERY INTIMAL MEDIUM THICKNESS IN CHILDREN WITH CHRONIC KIDNEY DISEASE

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Article

Created At

22 Jan 2023