The present study was carried out in order to investigate the efficiency of various formulations of silver-botanical nanoparticles, i.e. cloves, lantana camara and conyza dioscoridis as nematicide substitutes against the tomato root- knot nematode (M. incognita), in both laboratory and under greenhouse conditions. Results clarified that the tested normal and NE-extracts, significantly and drastically, increased (J2) mortality % and reduced egg-hatching and the effect increased with increasing compound concentration and exposure time. However, nanoparticles forms of all tested compounds consistently showed higher effect than normal extracts forms. Meanwhile, NP-L. camara showed the highest J2 mortality % and egg-hatching inhibition at all exposure times. The nanoparticles, dramatically reduced root galls, egg masses, eggs and final population of M. incognita infecting tomato plants at the application rate of 100 μg/ml. Meanwhile, the NP-L. camara treatment was the most efficient in reducing root galls, egg masses, eggs and population of J2 in soil, followed by NP-Cloves and NP-C. dioscoridis. Moreover, the different extracts treatments improved and increased the mean values of tomato growth parameters in the inoculated treated plants. NP-L. camara showed the highest growth parameters. However, most mean values of growth parameters for NP-Cloves treatment not significantly different from the NP-L. camara. Consequently, these nanoparticles extracts could be effective potentially and environmentally safe to control tomato knot-root nematode.