This study examined the inhibitors militating against artisanal fisherfolks in Epe Local Government Area, Lagos, Nigeria. A two-stage sampling procedure was used to select 120 respondents. Data were obtained by the use of a structured questionnaire. Based on the result the findings, most of the respondents were female (66.7%) with an average age of 44 years. The average farming experience was 12 years. Tilapia and Croaker (mean=3.99), Catfish (mean=3.98), Obokun fish (mean=3.97), Pink shrimp (mean=3.91), Ejaosan (mean=3.88), Abo (mean=3.06) and Akokoni (mean=3.03) were highly harvested fish among respondents. The top-ranked inhibitors were infestation of water by hyacinth (mean=2.67), inaccessibility to credit (mean=2.05), and inadequate technology (mean=2.02). Borrowing money (mean=2.27), Borrowing equipment (mean=2.05), and Servicing boats before breakdown (mean=1.68) were the leading coping strategies to inhibitors against fisher folks in the study area. PPMC results show that sex (r=0.254; p=0.006), education (r=0.233; p=0.012) and primary occupation (r=0.357; p=0.000) were socioeconomic characteristics that significantly affect inhibitors against fisher folks in the study area. There is a need for government to make funds available for arsenal fisher folks by creating loans through a bank of Agriculture. Fisherfolks should also be enlightened through extension programs on how to control water hyacinth, improvement of fishing practices, and technology adoption.