This study was carried out during 2018 and 2019 seasons for examining humic acid and amino acids effects on the yield and fruit quality of Manfalouty pomegranate trees grown under Assiut region circumstances. The experiment was set up in a complete randomized block design with three replicates, one tree per each. Manfalouty pomegranate trees were treating with humic acid or amino acids three times. Spraying humic acid at (1, 2 and 3 %) or amino acids at (0.5, 1 and 1.5%) was very effective in stimulating all physical and chemical characteristics of the fruits relative to spray with water (control). Humic acid (3%) spraying gave the highest yield followed by amino acids (1.5%). On the other side, all treatments significantly decreased the fruit cracking percentage compared to control. The least fruit cracking was recorded due to amino acids at (0.5%) spraying. All treatments significantly increased fruit weight and fruit dimensions as well as arils percentage and juice contents compared to control. Moreover, humic acid at (1, 2 and 3 %) or amino acids at (0.5, 1 and 1.5%) significantly improved the fruit chemical constituents, compared to control. Spray via any concentration of humic acid or amino acids had no significant differences. It could be concluded that foliar application of either humic acid at 1% or amino acids at 0.5% three times during the fruit growth of manfalouty pomegranate, there application had necessary to get high yield and reduction fruit cracking percentage with best fruit quality.