The experiment was conducted in the Agronomy Department, Faculty of Agriculture, Sohag University, Egypt in winter season of 2019/2020 to identify the most appropriate wheat genotypes to water stress. Ten bread wheat genotypes (3 Egyptian cultivars and 7 imported accessions (were screened under osmotic stress with three drought stress treatments induced by PEG-6000 (polyethylene glycol) i.e. control, 5% and 10% PEG-6000 solutions. The analysis of variance indicated significant differences among treatments for all recorded germination parameters (GP, GIT, GMT, GDT, SP, MDG, MTG, GC, GV and GVI). Where GP, SP, GC, GV and GVI were decreased under low water potential, while the drought stress caused retarding of germination process, continued in long period, acted in increasing of GIT, GMT, GDT, MDG and MTG.Significant interactions revealed that wheat genotypes responded variably to osmotic stress treatments. Hence, that is provided better opportunity to select drought tolerant cultivars at germination stage. Tow genotypes; G3 and G10 (Misr 1) were very good tolerant to drought stress at 5% PEG and ranked as 1^st and 2^nd order, respectively. They produced the highest germination vigor, so the seedling will be in regular growth. In the severe stress induced by 10% PEG treatment, the genotype G3 was more superior more than the others in all germination parameters. In the end we can recommend the genotypes G3 and G10 (Misr1) for drought stress conditions with modify their seeding rates ((100/GP in stress conditions) x optimal seeding rates).