The effect of high and low temperature and microwave radiation on the adult of the lesser grain borer, Rhyzopertha dominica (F.) infested wheat seeds was studied. At high temperature (55°C), 29% of the death occurred after 30 minutes and the complete death occurred after 60 minutes. The lethal time of 50% mortality (LT50) and lethal time of 90% mortality (LT90) values were 36.96 and 63.4 minutes. Cold temperature (-7°C) caused 12% mortality after 20 minutes and complete succumb was obtained after 75 minutes. The LT50 and LT90 values were 38.6 and 71.3 minutes. Microwave at power of 2450 MHZ caused 33% mortality after 10 seconds and 100% mortality after 35 seconds. The LT50 and LT90 values on this power were 12.8 and 26.3 seconds. The mean germination rate of wheat seeds was 5% for microwave treatment (2450 MHZ, 30 seconds). However, 70% germination rate was achieved when the seeds were exposed to low temperature (-7°C, 3 months), and 77.5% when high temperature (55°C, 60 minutes) were used. In conclusion, the present study showed that, cold temperature (-7°c), high temperature (55°c), and microwave radiation had been successfully controlled R. dominica in a short period of time, however, microwave radiation had adverse effects on the germination of wheat seeds. Radiation seeds should therefore not be used in planting.