Schistosomiasis is one of the most prevalent parasites causing morbidity. Praziquantel (PZQ)
is recommended drug for all Schistosoma spp. But, it exhibits low and erratic bioavailability and
drug resistance. This study evaluated the anti-parasitic and anti-fibrotic effects of resveratrol
(RSV) loaded on niosomes in murine schistosomiasis mansoni. Mice were divided into 3 groups:
GI (control) subdivided into (Ia) uninfected untreated, (Ib) infected untreated, and (Ic) infected
treated with niosomes nanoparticles (NPs). GII: received niosomes-PZQ and subdivided into
(IIa) received a dose of 250mg/kg body weight /24hrs in 2 doses of 3hrs apart at 4th wk. P.I. (antiparasitic)
and (IIb) received a dose of 500mg/kg body weight divided equally on 2 consecutive
days at 10th wk. P.I. (antifibrotic). GIII: subdivided into 2 subgroups (IIIa & IIIb) received niosomes-
RSV in a dose of 20mg/kg bodyweight /24hrs 3 times a week for 2 wks. at 4th & 10th wks.
P.I. respectively. All mice were subjected to parasitological, histopathological, & immunohistochemical
(α-SMA) studies, as well as, ALT & AST serum levels evaluation. Niosomes-RSV
caused significant reduction in adults' count, hepatic eggs, ALT & AST levels and hepatic granulomas'
size and number. Niosomes NPs alone caused significant reduction only in adults' count
and hepatic eggs compared to infected untreated ones.