257713

CROSS NEUTRALIZATION OF SOME KINDS OF VIPERS AND SNAKE VENOMS FROM AFRICA AND MIDDLE EAST USING VACSERA POLYVALENT VIPER ANTISERA

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

-

Abstract

As the death rate due to snake bites was differ enormously between different countries, the
study conducted was an extensive of neutralization of lethality of two species of genus Naja,
seven species of genus Vipera, and two species of Macrovipera by using VACSERA equine
antisera. The results showed that polyvalent snake venom antisera from VACSERA (which
was prepared by injection of horses by Cerrastes cerastes, and Echis carinatus) was highly
effective in neutralizing specifically to venom used for immunization and para-specifically to
other species including Naja haje, Naja nigricollis, Vipera palastinae, Vipera xanthina, Vipera
ammodytes, Echis coloratus, Cerastes vipera and Pseudoechis beside Macrovipera species
including Macrovipera lebetina obtuse, Macrovipera lebetina turanica. The present
study was established for whether specific or para-specific neutralization exists, its extent
and the potency of para-specific versus specific neutralization within and between each
genus, leading to wide spread of VACSERA Viper antivenom within the different countries.

DOI

10.21608/jesp.2022.257713

Keywords

Cross Neutralization, Venoms, LD50, ED50, Elapidae, Vipredae, Macrovipera

Authors

First Name

ABIR

Last Name

ELFIKY

MiddleName

A.

Affiliation

Department of ANDI Coe in Antivenom Research, CEO of EGYVAC, VACSERA, Dokki

Email

-

City

-

Orcid

-

First Name

ERENE

Last Name

GIRGIS

MiddleName

F.

Affiliation

Department of ANDI Coe in Antivenom Research, CEO of EGYVAC, VACSERA, Dokki

Email

-

City

-

Orcid

-

First Name

MOHAMED

Last Name

ZID

MiddleName

M.

Affiliation

Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Giza, Egypt

Email

-

City

-

Orcid

-

First Name

YASMIN

Last Name

MOHAMED

MiddleName

E.

Affiliation

Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Giza, Egypt

Email

-

City

-

Orcid

-

Volume

52

Article Issue

2

Related Issue

36454

Issue Date

2022-08-01

Receive Date

2022-09-03

Publish Date

2022-08-01

Page Start

363

Page End

370

Print ISSN

1110-0583

Online ISSN

2090-2549

Link

https://jesp.journals.ekb.eg/article_257713.html

Detail API

https://jesp.journals.ekb.eg/service?article_code=257713

Order

257,713

Publication Type

Journal

Publication Title

Journal of the Egyptian Society of Parasitology

Publication Link

https://jesp.journals.ekb.eg/

MainTitle

CROSS NEUTRALIZATION OF SOME KINDS OF VIPERS AND SNAKE VENOMS FROM AFRICA AND MIDDLE EAST USING VACSERA POLYVALENT VIPER ANTISERA

Details

Type

Article

Created At

22 Jan 2023