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235818

EFFECT OF LACTOBACILLUS ACIDOPHILUS ON TRICHINELLA SPIRALIS MUSCLE LARVAE IN EXPERIMENTALLY INFECTED MICE COMPARED TO ITS EFFECT WHEN COMBINED WITH ALBENDAZOLE AND/OR NITAZOXANIDE

Article

Last updated: 25 Dec 2024

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Abstract

This study evaluated the therapeutic and synergistic effects of Lactobacillus acidophilus (L.
acidophilus), a probiotic, and nitazoxanide (NTZ) as compared to the used, albendazole (ABZ),
as single therapy and in combination. ABZ/L. acidophilus-treated group showed the highest
reduction of encysted larvae (92.5%) as compared to control and to ABZ-treated mice. Also,
NTZ treatment showed a significant decrease in larval counts compared to control (40.95%),
which was comparable to that produced by L. acidophilus single therapy. But, combined NTZ
with L. acidophilus caused a significantly higher reduction of larvae (56.62%) highlighted synergistic
abilities of both. Histopathological examination showed marked decrease in larval
counts and inflammatory reactions in ABZ/L. acidophilus-treated group. Combined L. acidophilus
with other therapeutics caused increased eosinophilia degeneration and larval replacement.

DOI

10.21608/jesp.2022.235818

Keywords

Trichinella spiralis larvae, Lactobacillus acidophilus, Nitazoxanide, albendazole

Authors

First Name

NARDEEN

Last Name

BOCKTOR

MiddleName

ZAKKA

Affiliation

Department of Medical Parasitology, Faculty of Medicine, Cairo University, Egypt

Email

nzbocktor@kasralainy.edu.eg

City

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Orcid

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First Name

MOHAMED

Last Name

EL-SAIED

MiddleName

-

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Cairo University

Email

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City

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Orcid

-

First Name

NAGLAA

Last Name

IMAM

MiddleName

F. A.

Affiliation

Department of Medical Parasitology, Faculty of Medicine, Cairo University, Egypt

Email

-

City

-

Orcid

-

Volume

52

Article Issue

1

Related Issue

33960

Issue Date

2022-05-01

Receive Date

2022-05-09

Publish Date

2022-05-01

Page Start

107

Page End

116

Print ISSN

1110-0583

Online ISSN

2090-2549

Link

https://jesp.journals.ekb.eg/article_235818.html

Detail API

https://jesp.journals.ekb.eg/service?article_code=235818

Order

13

Type

Original Article

Type Code

1,127

Publication Type

Journal

Publication Title

Journal of the Egyptian Society of Parasitology

Publication Link

https://jesp.journals.ekb.eg/

MainTitle

EFFECT OF LACTOBACILLUS ACIDOPHILUS ON TRICHINELLA SPIRALIS MUSCLE LARVAE IN EXPERIMENTALLY INFECTED MICE COMPARED TO ITS EFFECT WHEN COMBINED WITH ALBENDAZOLE AND/OR NITAZOXANIDE

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Article

Created At

22 Jan 2023