Arthropod venoms have multiple effect on antivirus and antibacterial infection especially,
bee venom (BV), which has a specific character among other due to its ant-proliferative potential,
antiviral, antimicrobial and antitumor activity. Venom-based drugs as Captopril® & Ribavirim
® are used as antiviral and anticancer drug. Empathetic the action mechanism of venompeptides
increase the drug specificity against virus cells. A new coronavirus (SARS-CoV-2)
leads to an incipient coronavirus disease (COVID-19). COVID-19 virus belongs to genus Betacorona
virus that includes MERS-CoV & SARS-CoV. The study evaluated venom derivatives
and antiviral drugs against COVID-19 envelope protein (EP) and spike protein (SP) sequences.
In this study, sequence analysis, protein modeling, & molecular docking were used for
COVID-19 EP, and SP, to build a model of testing venom derivatives and antiviral drugs against
COVID-19 EP, and SP. Approved drugs includes Remdisivir®, Ledipasvir® (antiviral drugs),
Captopril®, & Ribavirim® (as venom antiviral drug derivatives).