Several studies demonstrated a high seroprevalence of Toxoplasma gondii in schizophrenic
patients than healthy individuals. This case control study determined the serprevalence of T.
gondii among schizophrenic patients and healthy individuals at Kafrelsheikh University
Hospitals and to estimate its effect on serum dopamine level. T. gondii IgG was detected in
52.2% &23.9% of schizophrenic patients and healthy individuals respectively with significance
(P value = 0.005). Serum dopamine level was higher in schizophrenic patients than
healthy individuals with statistical significance (P = <0.001) and also higher in T. gondii IgG
positive than T. gondii IgG negative patients with statistical significance (P = <0.001).