Schistosomiasis is one of the major public health diseases that induced a diversity of immunologic
reactions. Significant association between autoreactive antibodies and autoimmune disorders
was suggested. This study investigated the presence of anti-double stranded DNA (anti-ds
DNA) antibodies and inflammatory biomarker, C-reactive protein (CRP) in 89 Egyptian patients,
with Schistosoma mansoni clinical evidence and high anti-Schistosoma antibody titer. The
results showed positive serum anti-ds DNA antibodies in 11/89(12.4%) of them, without significance
to age, sex or anti-Schistosoma antibody titers. CRP was positive in 20/89(22.5%) of patients,
with significant correlation with anti-ds DNA antibodies (P=0.000).