Intrahepatic distant recurrence, after successful radiofrequency ablation for hepatocellular
carcinoma, is related to many factors. Underlying liver fibrosis/cirrhosis severity thought to be
one of these contributors. FIB-4 index is a non-invasive marker which reflects the severity of
liver fibrosis. The aim of this study was to evaluate the prognostic value of FIB-4 index after
radiofrequency ablation for hepatocellular carcinoma with curative intent. This retrospective
study included 121 HCV related hepatocellular carcinoma patients with Child class A who underwent
radiofrequency ablation between 1/2010 & 12/2014. The study assessed the overall
survival and denovo intrahepatic distant recurrence using pretreatment FIB-4 index.
The result showed that pretreatment FIB-4 index of ≤3.25 patients had significant better free
intrahepatic distant recurrence and overall survival rates after radiofrequency ablation when compared
to those with pretreatment FIB-4 index of > 3.25, even in subsets of patients with Child
score 5, single lesion or lesions< 3cm. Also, FIB-4 index was useful prognostic predictor of intrahepatic
distant recurrence and overall survival after radiofrequency ablation in Child class A
patients in uni and multivraite analysis.