Tracing the etiology of paediatric neurological disorders back to toxoplasmosis was often difficult
and particularly challenged, depended mainly on serology in common practice. The current
study evaluated the role of toxoplasmosis and oxidative stress in Egyptian children suffering
from acute neurodevelopmental disorders, by seroprevalence in relation to IFN gamma in patients
with positivity for IgG & IgM. The result showed that out of 155 patients, 128 (82.6%)
were positive for IgG and 10 (6.5%) were positive for both IgG & IgM. Also, the serum
malondialdehyde (MDA) was significantly higher in seropositive pa-tients than in seronegative
ones. Six children suffered from acute toxoplasmosis showed high levels of serum IFN gamma.