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BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE

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Last updated: 25 Dec 2024

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Abstract

Schistosomiasis is a chronic disease with considerable social impact. Despite the availability of affordable chemotherapy, drug treatment has not significantly reduced the overall number of disease cases. Among other mechanisms, the parasite produces PGE2 and PGD2 to evade host immune defenses. To investigate the role of PGE2 and PGD2 in schistosomiasis, we evaluated the effects of L-161,982, Ah6809 (PGE2 receptor antagonists alone or combined with each other) and MK-0524 (PGD2 receptor antagonist) during prepatent Schistosoma mansoni infection. Drugs were administered intraperitoneally an hour before and 24 hours after infection of C57BL/6 mice with 100 Schistosoma mansoni cercariae. L-161,982, Ah6809, their combination and MK-0524 caused partial protection against pre-patent S. mansoni infection which was mediated by biasing the immune response towards Th1 phenotype. These results showed that blockade of PGE2 and PGD2 receptors confers partial protection against pre-patent S. mansoni infection in mice and that they may be useful as adjunctive therapy to current anti-schistosomal drugs or vaccines.

DOI

10.21608/jesp.2015.96281

Keywords

Schistosoma mansoni, PGE2, PGD2, receptor, blocker

Authors

First Name

RASHA

Last Name

ABDEL-GHANY

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Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.

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First Name

IBRAHIM

Last Name

RABIA

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-

Affiliation

Department of Parasitology, Theodor Bilharz Research Institute, P.O. Box 30 Imbaba, Giza, 12411, Egypt.

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First Name

EMAN

Last Name

EL-AHWANY

MiddleName

-

Affiliation

Department of Immunology, Theodor Bilharz Research Institute, P.O. Box 30 Imbaba, Giza, 12411, Egypt.

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First Name

SAMEH

Last Name

SABER

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-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.

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-

Orcid

-

First Name

RASHA

Last Name

GAMAL

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-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.

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First Name

FATEN

Last Name

NAGY

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-

Affiliation

Department of Immunology, Theodor Bilharz Research Institute, P.O. Box 30 Imbaba, Giza, 12411, Egypt.

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First Name

OLAA

Last Name

MAHMOUD

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Affiliation

Department of Haematology, Theodor Bilharz Research Institute, P.O. Box 30 Imbaba, Giza, 12411, Egypt.

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Orcid

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First Name

RABAB

Last Name

HAMAD

MiddleName

SALEM

Affiliation

Department of Central Laboratory, Theodor Bilharz Research Institute, P.O. Box 30 Imbaba, Giza, 12411, Egypt.+, Department Biological Sciences, King Faisal University, P.O. Box 380, Hofouf 31982, Saudi Arabia.

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First Name

WALEED

Last Name

BARAKAT

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-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.

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Volume

45

Article Issue

3

Related Issue

14487

Issue Date

2015-12-01

Receive Date

2020-06-17

Publish Date

2015-12-01

Page Start

511

Page End

520

Print ISSN

1110-0583

Online ISSN

2090-2549

Article File

JESP_Volume 45_Issue 3_Pages 511-520.pdf

PDF . 431.9kB

Link

https://jesp.journals.ekb.eg/article_96281.html

Detail API

https://jesp.journals.ekb.eg/service?article_code=96281

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6

Type

Original Article

Type Code

1,127

Publication Type

Journal

Publication Title

Journal of the Egyptian Society of Parasitology

Publication Link

https://jesp.journals.ekb.eg/

MainTitle

BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE

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Article

Created At

22 Jan 2023