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94825

HISTOPATHOLOGICAL CHANGES IN LIVER OF MICE AFTER EXPERIMENTAL ENVENOMATION WITH ANDROCTONUS AMOREUXI SCORPION VENOM

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Last updated: 25 Dec 2024

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Abstract

A total of 78 adult male Albino mice were divided into thirteen groups (6 mice in each). One served as a control group and the other twelve groups were venom treated groups. The mice of treated groups were injected with 0.1 ml saline solution
in which a particular amount of scorpion venom. The first 6 groups were subcutaneously injected with 1/2 LD50 (0.05 g/g body weight), while the other 6 groups were injected with 1/4 LD 50 (0.025 g/g body weight) by the same route.
The animals from each group were anesthetized with ethyl ether and sacrificed at different time intervals (3, 6, 9, 12 hrs, 4 & 7days post toxin administration). The microscopic examination of liver tissue obtained from envenomed animals
showed variable histopathological changes being severely increased with the time interval of envenoming. The most obvious changes in the liver were acute cellular swelling, hydropic degeneration, congestion of central veins and portal blood vessels. Besides, extramedullary hematopoiesis and invaginations in nuclei of hepatic cells, with formation of intranuclear cytoplasmic inclusions were observed.

DOI

10.21608/jesp.2013.94825

Keywords

Egypt, Androctonus amoreuxi, Venom, histopathology, Liver

Authors

First Name

HAMDY

Last Name

FETAIH

MiddleName

A.

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Suez Canal University, Egypt.

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First Name

NAHLA

Last Name

SHOUKRY

MiddleName

M.

Affiliation

Department of Zoology, Faculty of Science, Suez University, Suez, Egypt.

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Orcid

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First Name

BELAL

Last Name

SOLIMAN

MiddleName

A.

Affiliation

Department of Zoology, Faculty of Science, Suez University, Suez, Egypt.

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City

-

Orcid

-

First Name

MAHMOUD

Last Name

MOHALLAL

MiddleName

E.

Affiliation

Department of Zoology, Faculty of Science, Suez Canal University, Egypt.

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-

City

-

Orcid

-

First Name

HOWAYDA.

Last Name

KHALED

MiddleName

S.

Affiliation

Department of Zoology, Faculty of Science, Suez University, Suez, Egypt.

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Volume

43

Article Issue

2

Related Issue

14305

Issue Date

2013-08-01

Receive Date

2020-06-10

Publish Date

2013-08-01

Page Start

447

Page End

456

Print ISSN

1110-0583

Online ISSN

2090-2549

Link

https://jesp.journals.ekb.eg/article_94825.html

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https://jesp.journals.ekb.eg/service?article_code=94825

Order

16

Type

Original Article

Type Code

1,127

Publication Type

Journal

Publication Title

Journal of the Egyptian Society of Parasitology

Publication Link

https://jesp.journals.ekb.eg/

MainTitle

HISTOPATHOLOGICAL CHANGES IN LIVER OF MICE AFTER EXPERIMENTAL ENVENOMATION WITH ANDROCTONUS AMOREUXI SCORPION VENOM

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Article

Created At

22 Jan 2023