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PERIOPERATIVE ACUTE PHASE RESPONSE AND OUTCOME OF HEPATIC RESECTION, AN EXPERIMENTAL STUDY

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Last updated: 25 Dec 2024

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Abstract

Identification of patients at risk of postoperative complications could have an impact on the indications for a procedure as well as permitting modifications of treatment to reduce the surgical risk. This experimental study evaluated the correlation between peri-operative acute phase response and outcome of hepatic resection. The study was conducted on sixty healthy golden hamsters, which underwent partial hepatectomy. They were arranged in 3 groups (20 per each). One day prior
to resection, fracture of the left hind leg was done in group I (G I) & wound infection had been created in group II (GII); while nothing done in group III (GIII) that acted as a control. Blood samples to estimate SGPT and serum albumin (as
basic investigations for hamsters liver function) and serum IL–6 and CRP (as acute phase reactants) were taken preoperatively, immediately after resection and for the consecutive 3 days post operatively. The mean serum level of both acute phase reactants increased in GI and GII preoperatively and continues to rise immediately after resection. Post-operatively; among the three groups, the mean serum level of both reactants was higher in GI than in GII that was in turn higher than in GIII except when the postoperative complications were more severe than the other group, then this relation changed.

DOI

10.21608/jesp.2013.94811

Keywords

Hamster, partial hepatectomy, Hepatic Resection, surgical risk

Authors

First Name

MOHAMED

Last Name

ABBAS

MiddleName

-

Affiliation

Department of General Surgery, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.

Email

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City

-

Orcid

-

First Name

YOUSSEF

Last Name

FAROUK

MiddleName

-

Affiliation

Department of General Surgery, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

AHMED

Last Name

HASSAN

MiddleName

ABDELAZIZ

Affiliation

Department of General Surgery, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

MOHAMED

Last Name

HEDAYA

MiddleName

SAIED

Affiliation

Department of General Surgery, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

HUSSAM

Last Name

HAMDY

MiddleName

-

Affiliation

Department of General Surgery, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

HUSSEIN

Last Name

EZZAT

MiddleName

-

Affiliation

Department of General Surgery, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.

Email

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City

-

Orcid

-

First Name

SAYED

Last Name

MAREI

MiddleName

-

Affiliation

Department of General Surgery, Faculty of Medicine, Cairo University, Egypt.

Email

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City

-

Orcid

-

First Name

HANAA

Last Name

ARNAOUT

MiddleName

HAMED

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Cairo University, Egypt.

Email

-

City

-

Orcid

-

First Name

MONA

Last Name

NOSSEIR

MiddleName

-

Affiliation

Department of Pathology, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

MERVAT

Last Name

ELDAMARAWY

MiddleName

-

Affiliation

Department of ICU, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.

Email

-

City

-

Orcid

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Volume

43

Article Issue

2

Related Issue

14305

Issue Date

2013-08-01

Receive Date

2020-06-10

Publish Date

2013-08-01

Page Start

341

Page End

350

Print ISSN

1110-0583

Online ISSN

2090-2549

Article File

JESP_Volume 43_Issue 2_Pages 341-350.pdf

PDF . 316.4kB

Link

https://jesp.journals.ekb.eg/article_94811.html

Detail API

https://jesp.journals.ekb.eg/service?article_code=94811

Order

6

Type

Original Article

Type Code

1,127

Publication Type

Journal

Publication Title

Journal of the Egyptian Society of Parasitology

Publication Link

https://jesp.journals.ekb.eg/

MainTitle

PERIOPERATIVE ACUTE PHASE RESPONSE AND OUTCOME OF HEPATIC RESECTION, AN EXPERIMENTAL STUDY

Details

Type

Article

Created At

22 Jan 2023