This study evaluated the effect of dexemeditomedine and propofol on the prevention of emergence agitation following sevoflurane anesthesia in children. Sixty children, aged 4-6 years, ASA I, who were undergoing inguinal hernia repair were enrolled after written informed consents were obtained from parents of all participants. The results showed that the incidence of EA showed statistical significant reduction in dexemedetomedine group (15%) than propofol group (20%) and much reduction than saline group (60%) with no difference in the discharge time, FLACC scale was clinically but not statistically lower in dexemedetomedine group than propofol group and much lower than saline group at all times with no significant difference in the number of patients administered fentanyl, Ramsay's sedation scale was clinically higher in dexemeditomedine group than propofol group and much higher than saline group at all times but without statistical difference, inspired sevoflurane concentration was statistically lower in dexemeditomedine group than the other two groups at all times except at T7, where it was reduced in both dexemeditomedine and propofol groups but the reduction was more in dexemeditomedine group and heart rate (HR) and mean arterial pressure (MAP) showed statistical significant reduction in dexemedetomedine group than the other two groups at all times compared to baseline value (T0) except at T7, where they were reduced in both dexemedetomedine and propofol groups. In dexemedetomedine group, eight cases (40%) showed reduction in HR and four cases (20%) showed reduction in MAP but only one case (5%) required atropine and other one (5%) required ephedrine while in propofol group, one case (5%) showed reduction in HR and other case (5%) showed reduction in MAP but did not require atropine or ephedrine respectively.