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90158

EVALUATION OF RIFAXIMIN IN MANAGEMENT OF HEPATIC ENCEPHALOPATHY

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Last updated: 25 Dec 2024

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Abstract

This study evaluated the efficacy of rifaximin versus lactulose in the treatment of hepatic encephalopathy (HE). The study population included 50 patients who were diagnosed to have signs of the first to third degree HE, according to the West Haven criteria and classified into two groups. GI: included 25 patients who had HE and were treated with lactulose syrup (laxolac) 90 ml daily divided into 3 doses for 7 days. GII: included 25 patients who had HE and were treated with rifaximin 1200 mg daily divided into 3 doses for 7 days. Patients in both groups also received other measures of treatment of HE as daily enema and protein restriction. Rifaximin significantly improved various subjective and measurable components of HE including mental status, behavior, asterixis, and serum ammonia concentration. In acute HE of grade 1 to grade 3, rifaximin may be a good alternative to non-absorbable disaccharides as it is broad spectrum, non-absorbable antibiotic with rapid action and little side effects. It is better tolerated, associated with less frequent and shorter hospitalization in comparison to lactulose.

DOI

10.21608/jesp.2014.90158

Keywords

Hospitalized patients, hepatic encephalopathy, Lactulose, Rifaximin

Authors

First Name

ALI

Last Name

WAHIB

MiddleName

A.

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Nasr City, Egypt.

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Orcid

-

First Name

M.

Last Name

SALEM

MiddleName

NEGM EL-DEEN

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Nasr City, Egypt.

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-

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-

Orcid

-

First Name

MOSTAFA

Last Name

AHMED

MiddleName

A.

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Nasr City, Egypt.

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-

City

-

Orcid

-

First Name

YASSER

Last Name

EL-DESSOUKY

MiddleName

M. M.

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Nasr City, Egypt.

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-

City

-

Orcid

-

First Name

DIAA

Last Name

EL-TIBY

MiddleName

M.

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Nasr City, Egypt.

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-

City

-

Orcid

-

First Name

KHALED

Last Name

EL-MOLA

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Nasr City, Egypt.

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City

-

Orcid

-

First Name

ABEER

Last Name

EL-SAYED

MiddleName

M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza, Egypt.

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Volume

44

Article Issue

3

Related Issue

13560

Issue Date

2014-12-01

Receive Date

2020-05-17

Publish Date

2014-12-01

Page Start

677

Page End

685

Print ISSN

1110-0583

Online ISSN

2090-2549

Article File

JESP_Volume 44_Issue 3_Pages 677-685.pdf

PDF . 245.3kB

Link

https://jesp.journals.ekb.eg/article_90158.html

Detail API

https://jesp.journals.ekb.eg/service?article_code=90158

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15

Type

Original Article

Type Code

1,127

Publication Type

Journal

Publication Title

Journal of the Egyptian Society of Parasitology

Publication Link

https://jesp.journals.ekb.eg/

MainTitle

EVALUATION OF RIFAXIMIN IN MANAGEMENT OF HEPATIC ENCEPHALOPATHY

Details

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Article

Created At

22 Jan 2023