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89734

PARTIAL PORTAL VEIN ARTERIALIZATION MAINTAINS REGENERATION AFTER CRITICAL MAJOR HEPATECTOMY: EXPERIMENTAL STUDY

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Last updated: 25 Dec 2024

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Abstract

Portal vein arterialization (PVA) is often referred to as a salvage procedure for insufficient arterial or portal inflow. Its main role focuses on two domains, liver transplantation and extensive surgery for malignancies of liver, biliary tract and pancreas. It has been applied in treatment of fulminant hepatic failure due to intoxications and as a bridging procedure for transplantation or re-transplant. Radical resections with arterial reconstruction are a major challenge for surgeons especially in prolonging survival in advanced malignancies of the liver or biliary tract. This study revi ited the benefits of this procedure to test the hypothesis of supporting a failing liver during critical period of regeneration following major hepatectomy with insufficient arterial inflow. The endpoints were to identify the histopathological and biochemical evidence of regeneration. The experimental design: 24 adult dogs of both sexes were included. They were divided into
3 groups: G1 (n=7): animals subjected to 65% hepatectomy (control), G2 (n= 8): animals subjected to 65% hepatectomy & hepatic artery ligation, G3 (n=8): animals subjected to 65% hepatectomy & partial portal vein arterialization (PPVA). Blood samples were taken for assessment of liver functions and blood gas analysis. Liver biopsy was assessed for morphological and histopathological changes of regeneration. Gross specimens were used to calculate the liver regeneration rate. Results showed the presence of mitotic activity and regeneration in groups with PPVA comparable to controls. No evidence of regeneration observed in G2. Shunt patency was confirmed by increase in PO2 levels of arterialized portal vein. A significant increase in the regeneration rate in groups with arterialized portal vein 1 week post procedure was noted.

DOI

10.21608/jesp.2015.89734

Keywords

Experimental study, Dog, Portal vein arterialization

Authors

First Name

MOHAMED

Last Name

ASHOUR

MiddleName

T.

Affiliation

Department of Surgery, Theodor Bilharz Research Institute, Imbaba P. O. Box 30, Egypt.

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First Name

MAGDY

Last Name

ELSEBAE

MiddleName

-

Affiliation

Department of Surgery, Theodor Bilharz Research Institute, Imbaba P. O. Box 30, Egypt.

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First Name

HUSSEIN

Last Name

EZZAT

MiddleName

-

Affiliation

Department of Surgery, Theodor Bilharz Research Institute, Imbaba P. O. Box 30, Egypt.

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-

Orcid

-

First Name

MOHAMMED

Last Name

HEDAYA

MiddleName

S.

Affiliation

Department of Surgery, Theodor Bilharz Research Institute, Imbaba P. O. Box 30, Egypt.

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-

City

-

Orcid

-

First Name

MOHAMED

Last Name

TAWEELA

MiddleName

N.H.

Affiliation

Department of Surgery, Faculty of Medicine, Al-Azhar University, Egypt.

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Orcid

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First Name

ABDU

Last Name

ELBANNA

MiddleName

-

Affiliation

Department of Surgery, Faculty of Medicine, Al-Azhar University, Egypt.

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Volume

45

Article Issue

1

Related Issue

13481

Issue Date

2015-04-01

Receive Date

2020-05-15

Publish Date

2015-04-01

Page Start

167

Page End

175

Print ISSN

1110-0583

Online ISSN

2090-2549

Link

https://jesp.journals.ekb.eg/article_89734.html

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https://jesp.journals.ekb.eg/service?article_code=89734

Order

20

Type

Original Article

Type Code

1,127

Publication Type

Journal

Publication Title

Journal of the Egyptian Society of Parasitology

Publication Link

https://jesp.journals.ekb.eg/

MainTitle

PARTIAL PORTAL VEIN ARTERIALIZATION MAINTAINS REGENERATION AFTER CRITICAL MAJOR HEPATECTOMY: EXPERIMENTAL STUDY

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Article

Created At

22 Jan 2023