The results of spigelian hernia repair with prolene hernia system in a prospective study were evaluated from October 2014 to December 2018 on 20 patients with spigelian hernia- 12 patients female and 8 patients male were operated using prolene hernia system (prolene mesh) repair. All had spigelian hernia most of the hernia located on right side. All patients had examination 2 week after operation and follow up every month up to one year, without major complication. There was three miled wound infection and was treated by antibiotic and that improved without removing the mesh. No recurrence after the operation sermoa was found in four patients three female and on male and was treated by aseptic aspiration of seroma and antibiotic. Mean hospital stay was 2 days. Because of low complication rate, no recurrent and short hospital stay spigelian hernia repair with the prolene hernia system is the operation of choice for spigelian hernia.