Urinary schistosomiasis is a chronic granulomatous inflammation affects many body systems including female genital tract. The present study determined the prevalence and infection intensity of urogenital schistosomiasis and made a retrospective analysis of histopathological changes in female genital tract affected by S. haematobium among female patients attended Sohag University Hospitals, from October 2016 to September 2019. A total of 100 fallopian tube, 50 cervical and 50 vaginal specimens were collected from 200 female patients (126 rural & 74 urban) aged between 20-50 years; suffering from infertility, bleeding, pelvic discomfort and or dyspareunia. Histopathological examination of tissue biopsies was performed. Urine examination for all participants was done to detect S. haematobium eggs and infection intensity by using a standard urine filtration technique. Seven specimens (7%) were documented to have fallopian tube, five (10%) cervical and two (4%) vaginal schistosomiasis. Twelve out of 14 genital schistosomiasis cases were rural (85.7%) and two cases were urban (14.3%). Urine examination revealed 18 Schistosoma haematobium egg positive samples out of 200 participants (9%), {6 (33.3%) with light infection intensity and 12 (66.7%) with heavy infection intensity}. Nine out of 14 female genital schistosomiasis (FGS) cases (64.2%) were positive for Schistosoma haematobium eggs in urine, eight (88.8%) of them with heavy infection intensity.