Schistosomiasis is endemic mainly in Africa and the Middle East Countries, causing acute and chronic clinical pathogenicity. This study evaluated the potential antischistosomal efficiency of allicin against S. mansoni infected mice. Twenty CD1 male Albino mice were divided into two groups (10 mice/group). G1 (infected and treated with 0.9% NaCl), and G2 (infected and treated with 20mL/kg of allicin). Seven weeks post-infection, each group was intraperitoneally injected with allicin (3 times/week), sacrificed at the end of the 8th-week. Liver was harvested for studing worm burden, egg load, and oogram pattern. The recovered worms from both groups were subject to SEM and DNA fragmentation tests to monitor the differences. The results showed a significant reduction in worm burden and changes in oogram pattern of
G2 mice as compared to G1 (control). Allicin gave marked deformation of oral, ventral suckers and atrophy of the tubercles as well as marked fragmentation of the worms DNA.