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77951

BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE

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Last updated: 25 Dec 2024

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Abstract

Entamoeba histolytica is an invasive parasite and results in intestinal inflammation and amebic liver abscess. Metronidazole is the main used drug for amoebiasis in both adults and children. However, metronidazole has some drawbacks such as having potential mutagenic effects in rats as well as the problem of the emergence of drug- resistance species makes the development of other safer drugs for amoebiasis is critical. In this study we assessed the ability of bee venom (BV) loaded chitosan (CS) nanoparticles to treat amoebiasis and that BV has antiamoebic effect as well as it is proved that orally administered BV loaded CS nanoparticles can be a more effective alternative drug for amoebiasis than subcutaneously injected BV.

DOI

10.21608/jesp.2017.77951

Keywords

Amoebiasis, Bee venom, Chitosan nanoparticles

Authors

First Name

AMANY

Last Name

SABER

MiddleName

EL SAYED

Affiliation

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

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First Name

ABDELWAHAB

Last Name

ABDELWAHAB

MiddleName

KHALIL

Affiliation

Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

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Orcid

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First Name

AZZA

Last Name

EL AMIR

MiddleName

MOHAMED

Affiliation

Department of Zoology, Faculty of Science, Cairo University,Giza, Egypt.

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Orcid

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First Name

MAMDOUH

Last Name

NASSAR

MiddleName

IBRAHIM

Affiliation

Department of Entomology, Faculty of Science, Cairo University, Giza, Egypt.

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-

City

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Orcid

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First Name

HUSSEIN

Last Name

ZOHDI

MiddleName

FOUAD

Affiliation

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

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Volume

47

Article Issue

2

Related Issue

11619

Issue Date

2017-08-01

Receive Date

2020-03-18

Publish Date

2017-08-01

Page Start

443

Page End

458

Print ISSN

1110-0583

Online ISSN

2090-2549

Article File

JESP_Volume 47_Issue 2_Pages 443-458.pdf

PDF . 1.8MB

Link

https://jesp.journals.ekb.eg/article_77951.html

Detail API

https://jesp.journals.ekb.eg/service?article_code=77951

Order

24

Type

Original Article

Type Code

1,127

Publication Type

Journal

Publication Title

Journal of the Egyptian Society of Parasitology

Publication Link

https://jesp.journals.ekb.eg/

MainTitle

BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE

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Article

Created At

22 Jan 2023