The present study investigated the prevalence of common intestinal parasites in association with H. pylori infection among a group of patients with the most common chronic disease prevalent in Egypt. These patients were known to be chronic liver disease with different etiology and followed up in gastroenterology out-patients clinic. They were 77 complaining of various abdominal symptoms either some or all symptoms such as; nausea, vomiting, abdominal pain, heart burn, flatulence, constipation, distension, melena and sometimes diarrhea. The diagnosis of chronic liver disease was confirmed by the history, clinical examination, laboratory investigations, and sonographic images. There were 37 males and 40 females with mean age (48.5+14.2). Types of liver diseases were liver cirrhosis in 28 patients and fatty liver in 49 patients (Non Alcoholic Fatty liver disease; NAFLD). None of the patients was diabetic. Afresh single fecal sample was collected from both patients and controls. Each sample was divided into two parts; one for examination of common intestinal parasites, and the other part for detection of H. pylori antigen by Copro-immunoassay. The results showed no significant difference among intestinal parasites in patients and controls. But, E. histolytic was the commonest parasite (48%) compared to; G. lamblia (4%), A. lumbricoides (5.3%), E. vermicularis (2.7%), S. mansoni (1.3%), 2/3 of patients with E. histolylica were co-infected with H. pylori infection. The prevalence of H. pylori infection was (81.8%) compared to controls (63%), with significant difference.