Bilharziasis is one of the most common parasitic diseases, mostly affecting the liver by causing the formation of granuloma and hepatic fibrosis, and historically endemic diseases in Egypt. Hundreds of studies examined the hepatic schistosomiasis pathogenesis to find out points for possible drug interference with disease progression and complications. The macrophages are the major source of CD14 in liver granulomas of S. mansoni-infected mice and CD14 might have
regulatory roles during infection. The current study evaluated the cellular expression of CD14 in livers of S. mansoni infected mice in comparison with healthy controls, for assessment of its potential regulatory role in schistosome-induced hepatic fibrosis. Histopathological study of livers of S. mansoni infected mice after 12 weeks of infection was conducted using routine H&E stain and M.T stain for tissue fibrosis. Immunohistochemical evaluation of CD14 positive cells was
also performed using DAB as a chromogen. The results showed upregulation of CD14 expression in infected mice, compared to healthy control mice, with variable percentage and different distribution in relation to granuloma type.