Red sea Governorate coordinates: N 25o 32' 1'', E 33o 26' 18'' and one of the borders Governorates. The Red Sea Coast length of 1080 km, from the Gulf of Suez, latitude 29 north, to the border of Sudan on latitude 22 north with about 306,000 living in area of about 203,685km2(January 2018), and it is divided into seven cities include Hurghada (capital), Safaga, Al-Kuseer, Ras Ghareb, Marsa Alam, Shalatin, Halaib. Four Cities Hurghada, Safaga, Al-Kuseer, Ras Ghareb were selected for entomological surveys where dengue fever was anticipated to be occurred at November 2017. A total number of 469 houses were participates survived, positive adult houses were 20.47% (96/469), while positive larvae houses were 10.23 % (48/469). The stogmoyia indices for the parameters of house index (HI), container index (CI) and Breteau index (BI) were (10.2, 7.0 &16) respectively. The survey yielded a total number of immature stages of Aedes aegypti of 92.22% (960/1041), or 92.5 % (888/960) for larvae and 7.5% (72/960) for pupa. The immature stages of other species were recorded 7.78% (81/1041), Aedes detritus, Culex pipiens, Cx. antennatus and Cx. perexiguus and represented 86.42% (70/81) for larvae and 13.58% (11/81) for pupa. Adults Ae. aegypti were 20.36% (90/442), but adult mosquito of other species were 79.64% (352/442). Adults Ae. aegypti at Hurghada showed resistant to deltamethrin, cyflothrin and bendiocarb, and suggested resistance to lambda-cyhalothrin, but they were susceptible to malathion. At Safaga City showed resistant for bendiocarb and susceptible to cyflothrin. Larvae of Aedes aegypti at Hurghada City showed resistant to chlorpyrifos, but susceptible to temephos. Also, at Safaga City showed susceptible to temephos insecticide.