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68072

A NON INVASIVE METHOD FOR DIAGNOSIS AND ASSESSMENT OF PORTAL HYPERTENSION IN EGYPTIAN CIRRHOTIC PATIENTS USING PLASMA MALONDIALDEHYDE LEVEL

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Last updated: 04 Jan 2025

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Abstract

Liver cirrhosis is a common disease affecting Egyptian patients. Complications of liver cirrhosis usually start once portal hypertension increases. To the authors' knowledge, there are no available non-invasive methods for assessment of the severity of portal hypertension. This study evaluated the value of plasma Malondialdehyde (MDA) - a lipid peroxide marker for oxidative stress, as a diagnostic biomarker, to assess severity of Portal Hypertension in Egyptian cirrhotic patients. It is a case-control study conducted on a total of 150 Egyptian patients divided into two groups. GI: 100 patients diagnosed as liver cirrhosis with esophageal varices proved by upper GIT endoscopy. GII: 50 normal controls. Serum MDA was measured by ELISA technique. The results showed that MDA assay between the two groups revealed significant statistical
difference between the two studied groups. Correlation between MDA and the clinical parameters in the cirrhotic group showed a significant positive correlation with ascites, Child Pugh score, varices grade, while there was no correlation with sex.

DOI

10.21608/jesp.2019.68072

Keywords

Malondialdehyde, Portal Hypertension, Liver cirrhosis

Authors

First Name

AHMED

Last Name

ALLAM

MiddleName

SAMIR

Affiliation

Departments of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt.

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Orcid

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First Name

AYMAN

Last Name

ANWAR

MiddleName

GAMIL

Affiliation

Departments of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt.

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-

City

-

Orcid

-

First Name

RAMY

Last Name

GHAIT

MiddleName

SAMIR

Affiliation

Departments of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt.

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-

City

-

Orcid

-

First Name

TAMER

Last Name

ABDEL RAHMAN

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt.

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City

-

Orcid

-

First Name

WALAA

Last Name

KABIEL

MiddleName

AHMED YOUSRY

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt.

Email

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City

-

Orcid

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First Name

HAYTHAM

Last Name

NASSER

MiddleName

M.

Affiliation

Department of Radiology, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt.

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-

City

-

Orcid

-

First Name

MOHAMED

Last Name

HASSANY

MiddleName

-

Affiliation

National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.

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Orcid

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Volume

49

Article Issue

3

Related Issue

10275

Issue Date

2019-12-01

Receive Date

2020-01-13

Publish Date

2019-12-01

Page Start

661

Page End

668

Print ISSN

1110-0583

Online ISSN

2090-2549

Article File

JESP_Volume 49_Issue 3_Pages 661-668.pdf

PDF . 362.0kB

Link

https://jesp.journals.ekb.eg/article_68072.html

Detail API

https://jesp.journals.ekb.eg/service?article_code=68072

Order

20

Type

Original Article

Type Code

1,127

Publication Type

Journal

Publication Title

Journal of the Egyptian Society of Parasitology

Publication Link

https://jesp.journals.ekb.eg/

MainTitle

A NON INVASIVE METHOD FOR DIAGNOSIS AND ASSESSMENT OF PORTAL HYPERTENSION IN EGYPTIAN CIRRHOTIC PATIENTS USING PLASMA MALONDIALDEHYDE LEVEL

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Type

Article

Created At

22 Jan 2023