Skeletal Class III is a common orthodontic problem, so, the effect of chin-cup therapy on craniocervical angulation was evaluated in this study. Eleven orthodontic female patients were selected with skeletal Class III malocclusion. Their ages ranged from nine to eleven years. Patients was treated by chin-cup appliance for about two years. Pre and post treatment cephalometrics was taken. Craniocervical angulation was recorded through certain cephalometric measurements. Statistical analysis revealed that, there was a significant changes of most of the measurements with increase of craniocervical angulation. It could be concluded that, chin-cup therapy could affect craniocervical angulation.