Objectives: This study was designed to evaluate and compare the effect of two commercially available casein phosphopeptide amorphous calcium phosphate preparations applied with or without stannous fluoride gel in the prevention and treatment of early enamel decalcification. Materials and methods: The material consisted of eighty freshly extracted premolars which were divided into 8 equal groups of 10 each. Four groups were used to evaluate the effectiveness of Tooth Mousse, Tooth Mousse combined with stannous fluoride gel and Topacal C-5 combined with stannous fluoride gel in the prevention of enamel demineralization around orthodontic brackets, using polarized light microscope. The other four groups were used to evaluate the effect of the same three techniques in the treatment of artificially induced white spot lesions, using stereomicroscopic imaging. Results: The teeth in the control group had the deepest lesions followed by the Tooth Mousse then the two combination groups. Similarly teeth which showed an improvement in the severity of the white spot lesions from the baseline scoring were only in the  test groups and the complete healing was only in the two combination groups, while worsening of white spots to white spots with cavitation was mainly seen in the control group. Conclusions: The three tested techniques proved to be able to reduce the rate of enamel demineralization around orthodontic brackets when compared with the control (no treatment). The three tested techniques proved to be able to treat the white spot lesions to a limited extent and to prevent their worsening into cavitations when compared with the control (no treatment). There were no statistically significant differences between the effects of the tested techniques neither in the prevention of enamel demineralization nor in the treatment of the white spot lesions.