Maxillary canines are the most commonly impacted teeth, second only to third molars. Maxillary canine impaction occurs in approximately 2% of the population and is twice as common in females as in males. Approximately one-third of impacted maxillary canines are located labially and two-thirds are located palatally. Lateral incisor demonstrates an important role in the etiology of palatally impacted canines. So, the objective of this study is to compare the difference in the shape of lateral incisor (crown-to-root angulation) adjacent to palatally and labially impacted canine using conventional 2D and 3D radiographs. Sample of this study consisted of 60 patients (32 females and 28 males) with a mean age of 13.94 years. For each subject, two sets of radiographs (panoramic and CBCT scan) had been obtained. These patients were divided into 2 groups: The first group consisted of 35 patients with palatally impacted maxillary canines; the second group consisted of 25 patients with labially impacted maxillary canines. The control group (third group) consisted of normally erupted maxillary canines (25 subjects). Crown to root angulations of lateral incisors were measured. t test for independent samples was used to assess the crown-root angulation of lateral incisors. The results revealed that There was no significant difference for crown root angulation of lateral incisor between palatally and labially impacted canines groups using panoramic x-ray or CBCT (P=0.831, 0.395 respectively). Insignificant difference was found between panorama and CBCT in determining crown-root angulation of lateral incisor. In impacted canines groups, the roots of the adjacent lateral incisors were more angulated compared to those adjacent to normally erupted canines.