The aim of the current study was to investigate the effect of commercially available Curodont on enamel surface with white spot lesions after orthodontic treatment. A total of 14 teeth with white spot lesions in orthodontically treated subjects aged 12 to 22 years were enrolled in this clinical study. All participants recently finished their treatment with fixed orthodontic appliances in the Department of Orthodontics at the Faculty of Dentistry for girls, Al-Azhar University. Digital periapical x-ray was taken before and after three months of curodont application. Comparisons between the measures of the baseline and post treatment images were calculated to determine the radiodenisty change (mineral content change) before and after treatment. Paired t-test was used to compare between enamel mineral content change before and after treatment. Also saliva was collected to measure the change of pH of saliva after three and six months, using saliva – check buffer Testing. The results showed that there was a statistically significant increase in enamel mineral content after treatment. The mean±standard deviation values of percentage increase were 25.7±16.1%. Conclusion: Curodont proved to be an effective remineralizing agent for treatment of enamel WSLs that occurred after orthodontic treatment.