Objective: Compare the effect of different fluoride releasing bonding agents in prevention of enamel demineralization around the orthodontic brackets. Materials and methods: 100 premolar used, these premolars were bonded by 5 bonding agents which were: group 1: Twenty brackets were bonded by Transbond XT adhesive (control group). group 2: Twenty brackets were bonded by Transbond plus color change adhesive. group 3: Twenty brackets were bonded by Transbond XT and covered by Fluoride. group 4: Twenty brackets were bonded by GC Fuji ORTHO lC. group 5: Twenty brackets were bonded by Ketac Cem, subjected to pH cycle for 21 days at room temperature then examined by visual examination and examined by electron microscope. Results: Fuji Ortho showed the least demineralization while composite (Transbond XT showed the most one in demineralization of teeth. Conclusion: Fuji Ortho L.C bonding agent showed the highest property in preventing of demineralization during orthodontic treatment