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77151

Evaluation of the effect of systemic omega-3 polyunsaturated fatty acids on post-orthodontic relapse in a rabbit model

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Last updated: 04 Jan 2025

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Abstract

 
 Introduction: Long term stability is the major goal of orthodontic treatment. Hence, a series of safe pharmacological agents have been investigated to increase osteoblastic activity around orthodontically moved teeth to help in retention and stability of their correction. Aim of the study: To evaluate the effect of systemic administration of Omega-3 fatty acids on post-orthodontic relapse, and to histologically assess bone changes concurrent with its administration in rabbits. Materials and Methods: Thirty two adult albino male rabbits were divided equally and randomly into two groups. Each group received NiTi coil springs installed on mandibular first molars and ligated to anterior incisors. Omega-3 or Saline were given from day one of orthodontic tooth movement (OTM) till end of relapse period by oral gavage. After 21 days of active OTM, appliances were removed from both groups to allow orthodontic relapse (OR); then amount and percentage of relapse were measuredon days 21, 28 and 42. Animals were sacrificed for histomorphometric analysis of alveolar bone remodeling. Results: A significant difference in relapse percentage was found on the third week of OR with means (66.04 ± 6.01 %) and (75.22 ± 13.61%) for experimental and control groups, respectively. Histomorphometric analysis showed a significant reduction in the area of active bone-resorptive lacunae and a significant increase in newly formed bone area related to omega-3 group. Conclusions: A strong evidence of the osteoblastic simulative effect of Omega-3 had been found with decreased percentage of OR after OTM.

DOI

10.21608/eos.2018.77151

Keywords

Oral gavage, omega-3, Rabbits, relapse

Authors

First Name

Asser

Last Name

Gad

MiddleName

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Affiliation

Orthodontic Department,Faculty of Dentistry, KafrElsheikh University.

Email

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City

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Orcid

-

First Name

Essam

Last Name

Abdallah

MiddleName

-

Affiliation

Orthodontic Department, Faculty of Dentistry, Alexandria University

Email

-

City

-

Orcid

-

First Name

Nadia

Last Name

ElHarouni

MiddleName

-

Affiliation

Orthodontic Department, Faculty of Dentistry, Alexandria University

Email

-

City

-

Orcid

-

First Name

Samia

Last Name

Soliman

MiddleName

-

Affiliation

Orthodontic Department, Faculty of Dentistry, Alexandria University

Email

-

City

-

Orcid

-

Volume

54

Article Issue

December 2018

Related Issue

11546

Issue Date

2018-12-01

Receive Date

2018-05-09

Publish Date

2018-12-04

Page Start

1

Page End

10

Print ISSN

1110-435X

Online ISSN

2812-5258

Article File

EOS_Volume 54_Issue December 2018_Pages 1-10.pdf

PDF . 529.7kB

Link

https://eos.journals.ekb.eg/article_77151.html

Detail API

https://eos.journals.ekb.eg/service?article_code=77151

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Original Article

Type Code

1,120

Publication Type

Journal

Publication Title

Egyptian Orthodontic Journal

Publication Link

https://eos.journals.ekb.eg/

MainTitle

Evaluation of the effect of systemic omega-3 polyunsaturated fatty acids on post-orthodontic relapse in a rabbit model

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Article

Created At

22 Jan 2023