The aim of the study was to evaluate the onset and intensity of pain induced after the insertion of fixed orthodontic appliances. Also, to compare analgesics versus non-analgesics pain management approach (protocols). Material and metho Material and methods: Material and methods: One ds: hundred and fifty patients, ranged from 13 to 22years of age were asked to answer a questionnaire previously prepared to fulfill the aim of this work. They were divided into three groups, 50 patients each: the first group was the control group. They used acetaminophen 500 mg orally when pain was felt (VAS ≥ 4). The second group was asked to use acetaminophen 500 mg orally 30 minutes before the procedure and the third group was asked to use bite wafer. Results: Results of this study revealed that there Results: was a significant difference in pain intensity between group I and the other two groups in the first 24hrs. Pain intensity was high in group I compared to groups II and III. While, comparison between group II and group III revealed non-significant difference (p>0.05). Time to first analgesia was significantly shorter in group I compared to either group II or III. While, comparison between groups II and III revealed non-significant difference. Analgesic consumption in group I was significantly bigger than the other two groups, with non-significant difference between these two groups. Conclusion: Either preoperative analgesia or bite w Conclusion: afer can effectively relief post-operative pain during orthodontic treatment.