CIt is generally known that there has been a massive interest about the climate change and its significant impacts on health, weather, social and even economic activities. Nevertheless, the Hot arid regions are mostly impacted by these consequences. It is well known that Tall buildings are considerably designed for iconicity and symbolism in most cultures. There is a strong evidence that most of the MENA (Middle east and north Africa) region cities are extremely using the energy efficiency techniques in most of their buildings especially for the tall buildings to adapt the consequences of the climate change despite of the UNEP (united nations environment program) official report which documented that there are economic and financial barriers for especially the developing countries in applying most of the energy efficiency technological techniques in buildings due to its expense. A gap in knowledge was found regarding the minimal focus of the natural air circulation design based for Tall buildings in most of the middle east countries to create a better natural ventilation and air flow tightness. The paper presents a theoretical basis and cases study analytical strategies. Adaptation mechanisms for tall buildings in the hot arid regions are also discussed. Summarily, our conclusion provide evidence that the environmental design of buildings must be the preliminary first action for facing the negative impacts of climate change in hot arid region developing countries then any other technological aids will be highly recommended if applied.