In recent years, overinflated tire pressure and the consequence of increased heavy vehicles` axle loads on flexible pavements responses have become a major source of worry, because of the higher stress levels induced within the flexible pavement which leads to extra damage. As a result, this research aims to assess the performance of the flexible pavement under varied axle loads and tire pressures of different trucks in Egypt. The 3D-Move V2.1 analysis program is a tool used to calculate the stresses and strains within pavement layers. The main conclusions that can be drawn from the analysis of the results is that there is a direct relation between pavement responses in terms of vertical strain z-z, normal strain x-x, and vertical displacement with each of tire pressure and axle load. Furthermore, the pavement responses are affected more by load than tire pressure. The vertical strain z-z is influenced not only by vertical stresses, but also by normal and radial stresses and the elastic modulus of the layer. Also, vertical strain developed at the bottom of the asphalt layer and the subgrade is not affected significantly by tire pressure. In addition, the effects of tire pressure on the horizontal strain at the bottom of the asphalt layer is much more than on the compressive strain above the subgrade. The important conclusion is increasing of wheel loads have a greater impact on rutting deterioration than fatigue. However, increasing tire pressure has a greater impact on fatigue deterioration than rutting.