This paper presents an innovative hybrid simulation modeling approach developed for supply chains. The model approach has been built to investigate different inventory policies and transportation strategies in a supply chain network that minimize the system wide cost. The complex system is modelled using the powerful discrete-event simulation software DOSIMIS-3 and C++ DLL is developed for this purpose. This Hybrid approach combines the analytical inventory models, heuristics transportation strategies approaches, and simulation models to model different network structures and operating distribution strategies in supply chains. The developed approach is described in detail for the analysis of supply chains. The results from experiments that demonstrate the benefits of the proposed architecture are discussed and presented.