The current research aims at developing seismic fragility curves for reinforced concrete framed structures in Egypt. For that purpose, four and eight-story R.C. frames were designed according to Egyptian Code of Practice. The frames were located in three seismic zones, i.e. Alexandria, Safaga and Taba. Incremental dynamic analysis was performed under ten ground motions to determine the yielding and collapse capacity of each building. Five performance levels, namely, operational (OP), immediate occupancy (IO), damage control (DC), life safety (LS) and collapse prevention (CP) were considered and monitored in the analysis. Fragility curves were developed for the structural models of the studied frames considering the five selected performance levels.