Background: Patients with massive burn areas have now
a greater chance of survival thanks to improved modalities
of new treatments. In some patients it is necessary to harvest
multiple skin grafts from the same donor site which is restricted
by the quality of the skin and the time required to recover;
this procedure can take a long time and may increase the
danger of bacterial contamination resulting in increased
morbidity and mortality in these individuals. Platelet-rich
fibrin is one of the newest autologous growth factors utilized
for wound management. PRF application can significantly
improve the wounds' condition by supplying growth factors
to the wound environment, which aid in the epithelialization
process's acceleration, resulting in cost-effective wound
management. This will allow multiple harvesting from the
same donor site, reducing costs, hospitalization time, scars,
and co-morbidities.
Aim of the Work: To assess the role of PRF in accelerating
wound healing in the donor site following skin grafting in
burn patients.
Patients and Methods: This prospective, controlled,
clinical trial study was done from April 2020 to April 2021
included 20 patients at the burn unit of El Demerdash Hospital,
Ain Shams University.
Results: The current study showed that healing days in
donor sites injected with PRF were lower than those of
controlled areas with statistical significance and mean epidermal
thickness was lower in the control area compared to PRF
injected areas with statistical significance.
Conclusion: PRF can significantly decrease the time of
donor wound healing compared to that of conventional
treatment.