This study was performed to examine the impact of three levels of artichoke leaves on obese rats suffering from liver damage triggered by carbon tetrachloride (CCl4). This study was designed as follows: Forty-eight male albino rats weighting  (200±10g) were utilized in this research. The rats were categorized into two main groups; Group 1 (the control negative group), included six rats that received a basal diet; Group 2  included 42 rats that received a high-fat diet (HFD) for six weeks to induce obesity. Subsequently, animals in Group 2 were treated with CC14 subcutaneous injection (for 14 days) to induce liver damage. Alanine amino transaminase (ALT), weight gain, aspartate amino transaminase (AST), as well as lipid profile were assessed in both groups after this period to ensure obesity as well as liver damage induction. The animals in Group 2 were subdivided into seven subgroups: Subgroup (1) received HFD and was utilized as positive controls. Subgroups (2, 3, and 4) received HFD containing (25g, 50g, and 100g dried Artichoke leaves/kg diet), respectively. Subgroups (5, 6, and 7) received a low-fat diet LFD containing (25g, 50g, and 100g dried Artichoke leaves/kg diet), respectively. By the end of the trial, feed intake and the proportion of gaining bodyweight were estimated. In addition, serum glucose, lipid profile, liver enzymes, and kidney functions were determined in all groups. The obtained results revealed that all groups treated demonstrated substantial improvement in these indices. Treatment of obese groups suffering from damage in the liver with a low-fat diet containing the three levels from artichoke leaves, induced a substantial improvement in these indices compared to the obese groups, which were suffering from liver damage and treated with an HFD containing the same levels from the artichoke. Based on these outcomes, we may infer that Artichoke leaves may improve the adverse effects of obesity and liver disease.