Helicobacter pylori (H. pylori) are Gram-negative bacteria that colonize human gastric mucosa, leading to chronic gastritis. Parasitic infections are associated with H. pylori infection.This work aims is to evaluate the association of H. pylori and/or intestinal parasites infection with anemia in Egypt. Blood and stool specimens of 32 Subjects: 17 males and 15 females, whose age ranged from 1.5-65 years were analyzed for H. pylori antigen using Rapid Anti H. pylori test. Stool specimens were also examined microscopically for the presence of parasite eggs or larvae/cysts per wet amount by the saline concentration method. Complete blood counts (CBC) were calculated using Blood Cell Counter. The results indicated thatout of the collected 32 samples 17 (53.1%) were males and 15 (46.9%) were females; 22 (68.8%) were infected (11 with H. pylori only (G1) and 11 with H. pylori and/or intestinal parasites (G2), 34.4% each) and 10 (31.2%) were not infected (control group). In the parasitic infected G2: 7 (63.6%) were infected with protozoa and 3 (27.3%) were infected with helminthes and 1 (9.1%) has mixed infection with both protozoa and helminthes. Highly significant changes (p < 0.05) were observed for Hemoglobin level, RBCs count, Hct, Mean Cell Volume (MCV) and Mean Cell Hemoglobin (MCH) that were measured in G1 and G2 than in the control. In conclusion, there are high prevalence of H. pylori and intestinal parasites infections and this was highly associated with anemia disease in the studied subjects.