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64038

Breast cancer subtypes criteria versus clinicopathological data

Article

Last updated: 25 Dec 2024

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Abstract

Breast cancer in women is the second most frequent cancer incidence, the breast cancer cases with varied histopathological and biological aspects reflect different attitudes that result in various therapy responses and should be given different therapeutic strategies.This study aimed to differentiate the breast cancer due to the histopathological and molecular criteria, the first is inflammatory breast cancer (IBC) or non-IBC, and the second is hormonal positive breast cancer (HP BC) or triple negative breast cancer (TN BC), and the third is lymphovascular invasion positive (LVI-p) or lymphovascular invasion negative (LVI-n).Overall 78 female diagnosed with breast carcinoma were enrolled in this study.  Using pathological, histological and molecular criteria to differentiate the breast cancer groups in tissue samples, and then we were statistically displayed some histopathological and molecular features for each group. The results indicated that most common age in breast cancer patient is 50, the tumor size in IBC, TN BC and LVI-p is significantly higher than non-IBC, HP BC and LVI-n respectively, the most common tumorgrade is grade II, the nodal status in IBC and TN BC is significantly higher than non-IBC and HP BC respectively, 95% of IBC and 87 % of non-IBC patients are diagnosed as invasive ductal carcinoma, and 5% of IBC and 8 % of non-IBC patients are diagnosed as invasive lobular carcinoma. In conclusion statistical analysis of breast cancer clinicopathological data might help in improving of cancer treatment strategies.

DOI

10.21608/idj.2019.64038

Keywords

: inflammatory breast cancer (IBC), hormonal positive breast cancer (HP BC), triple negative breast cancer (TN BC), lymphovascular invasion positive (LVI-p), lymphovascular invasion negative (LVI-n)

Authors

First Name

Mohamed

Last Name

Fares

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Al-Azhar University, Cairo, Egypt

Email

moh.fares.sci@gmail.com

City

Cairo

Orcid

-

First Name

Sherif

Last Name

Ibrahim

MiddleName

Abdelaziz

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Egypt.

Email

-

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

El-Shinawi

MiddleName

-

Affiliation

Department of General Surgery, Faculty of Medicine, Ain Shams University, Egypt.

Email

-

City

Cairo

Orcid

-

First Name

Mona

Last Name

Mohamedamed

MiddleName

Mostafa

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Egypt.

Email

-

City

Cairo

Orcid

-

Volume

8

Article Issue

1

Related Issue

9656

Issue Date

2019-12-01

Receive Date

2019-08-07

Publish Date

2019-12-01

Page Start

71

Page End

80

Print ISSN

2314-5536

Online ISSN

2314-5544

Link

https://ijd.journals.ekb.eg/article_64038.html

Detail API

https://ijd.journals.ekb.eg/service?article_code=64038

Order

6

Type

Original Article

Type Code

1,105

Publication Type

Journal

Publication Title

International Journal of Development

Publication Link

https://ijd.journals.ekb.eg/

MainTitle

Breast cancer subtypes criteria versus clinicopathological data

Details

Type

Article

Created At

22 Jan 2023