The spermatogenesis process is very complex and involves many processes that lead to giving normal sperm, these sperms are very important for Fertility in the male. The cytokines are very important in male fertility which gives a significant job in fertilization. The varicocele patient grade 1,2 and 3(n= 25 , 25 and 25 Respectively) compare with control patient  (n=13). The results of this study showed that cytokine level (interleukin 17 & 6) is a significant increase in varicocele patient compared with the control group, also a positive correlation was found between interleukin 17 & interleukin 6 in varicocele patient, while the result showed a negative correlation between interleukin 17 and the sperms concentration, sperm Progressive motility percent and sperm normal morphology present in a patient with varicocele grade 1,2 and 3 respectively (r= -0. 574, r = -0. 647and r = -0. 487).  Also a  negative correlation between interleukin 6 level and the sperms concentration , sperm Progressive motility percent and sperm normal morphology present in varicocele patient grade 1,2 and 3 Respectively (r= -0.467 , r = -0.324 and r = -0.307 ). The present study concludes that important role of interleukin 17 and interleukin 6 appears to be a key cytokine regulating local tissue inflammation, the study showed varicocele has a Harmful effect with the time on cytokines levels and increases the diameter.