Background: Prostate cancer is the most common cancer in a male of the reproductive system and associated with high mortality and Androgen-deprivation therapy (ADT) is a key component of treatment for aggressive and advanced prostate cancer. Objective: The aim of this study was to assess the serum urea and creatinine beside the measure of serum electrolytes (Na and K) in patients with prostate cancer under (ADT).Methodology: 100 Sudanese patients with prostate cancer (PCa) under (ADT) attended in Khartoum oncology hospital, Khartoum state. The study conducted in April and July 2018. The age of PCa patients ranged between (50 to73 years) and their mean 62.2 years. The blood samples were taken from each patient. The urea and creatinine were estimated using spectrophotometer methods and also the serum electrolytes were measured by using flame photometers methods. Results: The (mean±SD) of serum urea, creatinine, Na and K were (41.31±27.6mg/dl,1.26±0.93mg/dl,141.37±11.52mg/dl,4.38±3.89mg/dl) respectively. The concentration of serum urea, creatinine, Na and K were normal within a normal range. There was significantly (P=0.000) difference of serum urea among prostate cancer patients under ADT and there was a significant correlation between urea and creatinine and also between Na and K. Conclusion: In this study concluded that the ADT  has no effect on blood renal parameters among prostate cancer.