The Red Sea is characterized by its high temperature, pH and salinity in summary which affect greatly the eggs development and early hatched embryos of cephalopods. Therefore, the present work aims to study the structure of eyes and optic lobes of the hatchlings of the cuttlefish Sepia savignyi to know how these structures can help these juveniles to live in their habitats in the Red Sea. Also, the structures of these organs were compared with that in other hatchlings of cephalopods in other ecological niches. The results indicated that the anatomical structure of eyes and the optic lobes is related to their functions and the different needs of the lifestyle of hatchling of this cuttlefish in its environment in the Red Sea for swimming, sensation and foraging in its habitats.